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ERC Advanced Grant awarded to Frédéric Saudou

on the March 28, 2019

An european boost to explore pathogenic mechanisms in Huntington disease


The European Research Council announced on March 28th the selection of the winners of the "ERC Advanced Grant 2018". The Grenoble Institut Neuroscience, Université Grenoble Alpes, Inserm and the CHU Grenoble Alpes are proud to announce that Frédéric Saudou, director of the Grenoble Institut Neuroscience (UGA/Inserm) and UGA-CHUGA professor has been awarded the ERC Advanced grant on his project on Huntington’s disease.

Founded in 2007, the ERC funds the very best scientific projects at a pan-European level. Awarded annually, the ERC grants are currently considered as a significant Europe-wide recognition of excellence in the higher education and research. 2,052 research proposals were submitted this time, out of which almost 11% were selected for funding. 10 french scientists received funding in Life Science and two in Neurosciences among them frédéric Saudou.

The 3rd ERC Grant for Grenoble Institut Neuroscience

Since its creation, 3 ERC grants have been awarded to GIN’s researchers across all three categories: Advanced grants for the most experienced researchers (Frédéric Saudou this year), Consolidator grants for those with a few years’ experience (Olivier David in 2014), and Starting grants for those who are just setting out on their careers. the ERC Starting grant was awarded to Homaira Nawabi in 2017. To note : Olivier David also obtained an ERC Proof of Concept in 2018.

An european boost to explore pathogenic mechanisms in Huntington disease

The 3rd grant rewards Frédéric Saudou. His team studies the molecular mechanisms that leads to neurodegeneration Huntington’s disease (HD). "We are still far away to understand the complexity of the mechanisms leading to neurodegeneration in HD" says Frédéric Saudou.

Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington’s Disease
"We have found several years ago that an important function of HTT, the protein that when mutated causes HD plays a crucial role in boosting axonal transport of small vesicles that contain trophic factors. This transport, when altered has a deleterious effect to the brain. More recently, we have reported a new mechanism by which specific enzyme provide energy to axonal transport. We hypothesize in this project that HTT is key to regulate this energy supply and that defects in this mechanism could be participating to HD."

This project will help to understand how HTT regulates axonal transport and how energy homeostasis plays a key role in HD and potentially to other neurodegenerative disorders linked intracellular trafficking defects.

Updated on May 8, 2019

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